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51.
Monalisa Cesarino Gomes Matheus França Perazzo Erick Tássio Neves Maria Betânia Lins Dantas Siqueira Edja Maria Melo de Brito Costa Ane Polline Lacerda Protasio Adriana Freitas Lins Pimentel Silva Kátia Virgínia Guerra Botelho Ana Flávia Granville-Garcia 《Zeitschrift fur Gesundheitswissenschaften》2018,26(5):587-594
52.
Elsa D. Silva Pedro S. Babo Raquel Costa-Almeida Rui M.A. Domingues Bárbara B. Mendes Elvira Paz Paulo Freitas Márcia T. Rodrigues Pedro L. Granja Manuela E. Gomes 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(7):2375-2385
Photocrosslinkable magnetic hydrogels are attracting great interest for tissue engineering strategies due to their versatility and multifunctionality, including their remote controllability ex vivo, thus enabling engineering complex tissue interfaces. This study reports the development of a photocrosslinkable magnetic responsive hydrogel made of methacrylated chondroitin sulfate (MA-CS) enriched with platelet lysate (PL) with tunable features, envisioning their application in tendon-to-bone interface. MA-CS coated iron-based magnetic nanoparticles were incorporated to provide magnetic responsiveness to the hydrogel. Osteogenically differentiated adipose-derived stem cells and/or tendon-derived cells were encapsulated within the hydrogel, proliferating and expressing bone- and tendon-related markers. External magnetic field (EMF) application modulated the swelling, degradation and release of PL-derived growth factors, and impacted both cell morphology and the expression and synthesis of tendon- and bone-like matrix with a more evident effect in co-cultures. Overall, the developed magnetic responsive hydrogel represents a potential cell carrier system for interfacial tissue engineering with EMF-controlled properties. 相似文献
53.
Bart Hens Arjang Talattof Paulo Paixão Marival Bermejo Yasuhiro Tsume Raimar Löbenberg Gordon L. Amidon 《The AAPS journal》2018,20(3):57
For the last two decades, the application of physiologically based pharmacokinetic (PBPK) models has grown exponentially in the field of oral absorption and in a regulatory context. Although these models are widely used, their predictive power should be validated and optimized in order to rely on these models and to know exactly what is going on “under the hood”. In this study, an automated sensitivity analysis (ASA) was performed for 11 gastrointestinal (GI) variables that are integrated into the PBPK software program Simcyp®. The model of interest was a previously validated workspace that was able to predict the intraluminal and systemic behavior of two different suspensions of posaconazole in the Simcyp® Simulator. The sensitivity of the following GI parameters was evaluated in this model: gastric and duodenal pH, gastric and duodenal bicarbonate concentrations (reflecting buffer capacity), duodenal bile salts concentration, gastric emptying, the interdigestive migrating motor complex (IMMC), small intestinal transit time (SITT), gastric and jejunal volumes, and permeability. The most sensitive parameters were gastric/duodenal pH and gastric emptying, for both suspensions. The outcome of the sensitivity analyses highlights the important GI variables that must be integrated into an in vivo predictive dissolution test to help and create a rational and scientific framework/design for product development of novel and generic drug products. 相似文献
54.
55.
Paulo Roberto P. Urbano Luiz H. da Silva Nali Renato dos R Oliveira MS Laura M. Sumita Maria Cristina D. da Silva Fink Lígia C Pierrotti MD MS Camila da Silva Bicalho Elias David-Neto MD Cláudio S. Pannuti MD Camila M Romano 《Journal of medical virology》2019,91(6):1136-1141
BK virus is the causative agent of polyomavirus-associated nephropathy, a major cause of kidney transplant failure affecting 1%-10% of recipients. Previous studies that investigated the viral source on the kidney recipient pointed that the donor is implicated in the origin of human polyomavirus BK (BKPyV) infection in recipients, but giving the low genetic variability of BKPyV this subject is still controversial. The aim of this study was to determine if BKPyV replicating in kidney recipients after transplantation is always originated from the donor. Urine and blood samples from 68 pairs of living donors and kidney recipients who underwent renal transplantation from August 2010-September 2011 were screened for BKPyV by real time polymerase chain reaction. Only three recipients presented viremia. When both donors and recipients were BKPyV positive, a larger fragment of VP1 region was obtained and sequenced to determine the level of similarity between them. A phylogenetic tree was built for the 12 pairs of sequences obtained from urine and high level of similarity among all sequences was observed, indicating that homology inferences for donor and recipient viruses must be cautiously interpreted. However, a close inspection on the donor-recipient pairs sequences revealed that 3 of 12 pairs presented considerably different viruses and 4 of 12 presented mixed infection, indicating that the source of BKPyV infection is not exclusively derived from the donor. We report that about 60% of the renal recipients shed BKPyV genetically distinct from the donor, confronting the accepted concept that the donor is the main source of recipients’ infection. 相似文献
56.
Totino Paulo Renato Rivas de Souza Hugo Amorim dos Santos Correa Edmar Henrique Costa Daniel-Ribeiro Cláudio Tadeu Ferreira-da-Cruz Maria de Fátima 《Parasitology research》2019,118(1):377-382
Parasitology Research - It is known that premature elimination of non-parasitized RBCs (nRBCs) plays an important role in the pathogenesis of malarial anemia, in which suicidal death process... 相似文献
57.
Sónia Gonçalves Rita Ferreira Eva M. Conceição Cátia Silva Paulo P.P. Machado Emma Boyland Ana Vaz 《Journal of nutrition education and behavior》2018,50(5):451-457
Objective
This study explored whether a cartoon show with healthy eating messages positively affected children's food choices and food preferences.Design
Experimental between-subjects design.Setting
Four elementary schools in Portugal were investigated.Participants
Children (aged 4–8 years; n?=?142) were randomly assigned to 1 of 2 groups: a comparison group (n?=?73) was exposed to cartoons with no reference to food and an intervention group (n?=?69) was exposed to cartoons with healthy eating messages. After viewing, each child was given the opportunity to eat ad libitum for 10 minutes from a small selection of snack foods.Main Outcome Measure
Number of healthy and unhealthy food items chosen. Food preferences were measured using an adapted version of the Leeds Food Preference Checklist.Analysis
Generalized linear models were used to test for differences between groups. Results were considered significant at P?≤?.05.Results
Children in the experimental group chose significantly more healthy food items than did those in the comparison group (B?=?–.600; SE?=?.19; P?<?.05).Conclusions and Implications
Future studies may address the effect of prolonged exposure to healthy eating cartoons. Cartoons can be used to promote healthy food choices and can be a part of health promotion campaigns. 相似文献58.
59.
Amorim MM Borini CB Lopes SL Haiter-Neto F Bérzin F Caria PH 《Journal of Oral Science》2008,50(3):293-299
The aim of this study was to verify the relationship between the inclination of the coronoid process of the mandible, and electromyographic activity of the anterior part of the temporal muscle in skeletal Class I and II individuals. Forty-seven volunteers (mean age 24.5 +/- 3.9 years) were subdivided into two groups, according to angle ANB: Class I (n = 25) and II (n = 22). Two radiographic examinations were performed; one lateral cephalogram to measure angle ANB, and one frontal cephalogram to measure the inclination of the coronoid process. Electromyographic (EMG) examination of the anterior part of the subjects' temporal muscles was performed. Statistical analysis of the data showed that Class II individuals presented lower electromyographic activity of the anterior part of the temporal muscle. Based on the results obtained, it was concluded that the skeletal classes analyzed had no influence on the inclination of the coronoid process. The inclination of the coronoid process was not influenced by the electromyographic activity of the anterior part of the temporal muscle in Class I and II individuals; however, the lower electromyographic activity of the anterior part of the temporal muscle could be influenced by the skeletal class in Class II individuals. 相似文献
60.
da Silva PT Pappen FG Souza EM Dias JE Bonetti Filho I Carlos IZ Leonardo RT 《Brazilian dental journal》2008,19(3):228-231
This study evaluated in vitro the cytotoxicity of four root canal sealers (Topseal, EndoRez, TubliSeal and Kerr Pulp Canal Sealer E.W.T.) and their effects on reactive oxygen/nitrogen intermediate induction by mouse peritoneal macrophages. Thioglycollate-induced cells were obtained from Swiss mice by peritoneal lavage with 5 mL 10 mM phosphate-buffered saline, washed twice and resuspended (10(6) cells/mL) in appropriate medium for each test. Cytotoxicity was determined by the presence of hydrogen peroxide (H2O2) and nitric oxide (NO) by the peroxidase-dependent oxidation of phenol red and Griess reaction, respectively. Sealer suspensions were obtained in two different concentrations from each material: 18 mg/mL and 9 mg/mL, established according to compatibility parameters following MTT assay. Comparing the sealers, H2O2 release at concentrations of 9 mg/mL and 18 mg/mL was similar: Topseal > positive control (medium + cells + 5 mg/mL zimozan solution) > EndoRez > TubliSeal > Kerr Pulp E.W.T. > negative control (medium + cells). NO release at concentration of 9 mg/mL was: positive control (medium + cells + 10 microg/mL LPS solution) > Topseal > Kerr Pulp E.W.T. > TubliSeal = EndoRez > negative control (medium + cells); at concentration of 18 mg/mL was: positive control > Topseal > Kerr Pulp E.W.T > TubliSeal > EndoRez > negative control. Based on the results, it may be concluded that Topseal presented the highest cytotoxicity among the tested sealers, releasing higher concentrations of NO and H2O2 in macrophage culture. 相似文献